The KCNK12 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to KCNK12. This antibody recognizes Human, Mouse, and Rat antigen. The KCNK12 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. KCNK12 is expressed mainly in the brain and lung, but also observed in the kidneys, heart and skeletal muscle. KCNK12 is closely related to KCNK13 (58% identity at the amino acid level), but could not yet been functionally expressed in vitro and may require other proteins to become active